Neutron studies of HIV inhibitors reveal new areas for improvement
The first study of interactions between a common clinical inhibitor and the HIV-1 protease enzyme has been carried out by an international team with members from the US, Britain and France using neutrons at the Institut Laue-Langevin in Grenoble, France. It provides medical science with the first true picture of how an antiviral drug used to block virus replication actually works, and critically how its performance could be improved. The findings, reported in the Journal for Medicinal Chemistry , and the neutron techniques demonstrated at the ILL, will provide the basis for the design of a new generation of more effective pharmaceuticals to address issues such as drug resistance.
YSU's research reputation grows 'diffractometer by diffractometer' Ι ...
“One of the wonderful things about this instrumentation coming to YSU, as opposed to what you might see on other campuses, is that we’re going to have the ability for undergraduates to access this diffractometer, to be able to use it, have... Here, our undergraduates get a level of exposure that provides a means for them to go into the workforce with the experience that many other students at many other places will not have. “At other places, it might just be doctoral students or graduate students who get access to this level of equipment. Ryan announced at a news conference that the National Science Foundation had awarded a $470,000 grant to YSU to purchase two high-end X-ray diffractometers, which allows research of materials on the atomic level.
The Braggs' spectrometer
- The HFS X-ray stage has been used by the team to study the nanomaterials in an X-ray diffractometer enabling them to view the molecular structures in fine detail. The HFS X-ray stages are specifically designed for this established analytical technique
- WH had built the first diffractometer with a position sensitive detector. The two began putting every crystal they could think of into the beam. It is hard for us to imagine the shock created by the Braggs' paper on sodium chloride in 1913; salt
- The combination of a high stability multi-circle diffractometer and a 15-meter long small-angle x-ray scattering (SAXS) table at CHX will allow for both of these types of measurements to be performed on the same sample at the same beamline. Doing both